The Alzheimer’s calcium hypothesis is a Fantastic Voyage into your brain. And Elon Musk is mucking it up. This is pretty scary S**T!
BEFORE READING ON … ARE YOU, LIKE ME, A SENIOR WHO’S INTERESTED IN STAYING HEALTHY FOR YEARS TO COME? IF SO, YOU MIGHT LIKE TO SEE WHAT A SCIENTIST (ME) HAS TO SAY ABOUT HOW TO ACHIEVE IT AT NO EXTRA COST TO YOU, WITHOUT EVEN HAVING TO LEAVE HOME, STARTING HERE: HEALTHY AGING NATURALLY.
SIDENOTE: After reading this post, you’ll have a better idea of why drug companies are missing the boat on AD treatments. At the end of this article I’ll comment specifically on the latest FDA-approved drug and why it’s yet another abject failure from Big Pharma.
Now back to today’s ‘sponsor’ – …the Alzheimer’s calcium hypothesis
With apologies ahead of time – some (or a lot) of the information in this post might make your head hurt. Stick with it as much as you can, since this topic addresses perhaps the single most dangerous development ruining your brain health in the 21st century.
And it’s being perpetrated on all of us, without our consent. It’s led by a multibillion-dollar communications industry that owns every politician in the country. (In other words, don’t look for any of our ‘leaders’ do much about it, if anything.)
Your ignorance is their fuel.
Now let’s see what this is all about and how Elon Musk is one of the major drivers behind it.
First Up: What’s the Alzheimer’s Calcium Hypothesis?
Look, I know scientists like me talk funny. One of our biggest failings is communicating our research results to the public, in spite of the fact that most of it is taxpayer supported.
Mea culpa.
Nevertheless, I’ll do my best to explain in clear terms what the issue is with calcium and AD.
Whenever possible, I’ll lay out the science-y stuff, then explain what it means in plain(er) English.
Deal?
In the immortal words of Ace Ventura, Pet Detective, “Well, alrighty then.”
If you do a Google search with the terms (in quotes), “Alzheimer’s calcium hypothesis,” you’ll get a bit more than 430 results. The first two are the most interesting.
As of this writing, the first result is a very recent research study about modeling amyloid beta (amyloid-β or Aβ) pores to explain calcium toxicity (see Shah et al., 2022). In plain English, it involves explaining the behavior of the ‘pores’ behind the leakage of the Aβ protein known to muck up brain cells in AD.
The second result is a doctoral dissertation at the University of South Florida (Toglia, 2018).
I’m going to extract a key introductory passage from that dissertation in the way of describing the hypothesis in greater detail, as follows:
We find that as a result of exaggerated [Ca2+]i in FAD-causing mutant PS-expressing cells, the rate of oxygen consumption increases dramatically and overcomes the Ca2+ dependent enzymes that stimulate NADH production. This leads to decreased rates of proton pumping due to diminished membrane potential (4Ψm) along with less ATP and enhanced ROS production. These results show that through Ca2+ signaling disruption, mutant PS leads to mitochondrial dysfunction and potentially cell death.
Hoo-boy, I’ve got a lot of splainin’ to do, Lucy!
Let’s take one item at a time.
- FAD refers to Familial Alzheimer’s Disease
- PS refers to types of proteins (presenilins) that play roles in generating the Aβ protein
- [Ca2+]i or Ca+ are how we indicate ionic (charged) calcium
- NADH is a key electron energy transporter that life depends on
- Proton pumping is a key process for generating energy in mitochondria, the cell’s energy powerhouses
- Membrane potential is the voltage measured from one side of a membrane to another, expressed in millivolts (mV).
- ATP is the energy currency of the cell; it’s how we ‘spend’ cellular energy to stay alive
- ROS is the abbreviation for ‘reactive oxygen species’; when ROS levels rise too high, we get inflammation and diseases of all kinds
- Ca+ signaling disruption is exactly that; it’s one of the the root causes of mitochondrial dysfunction
- Mitochondrial dysfunction is the failure to generate sufficient cellular energy to maintain healthy life
- Accelerated cell death is what makes you a corpse before your time
All this happens with the exaggerated release of [Ca2+]i through special ion channels in membranes. Since the normal function of such channels depends on membrane potential (i.e., voltage), they’re referred to as voltage-gated calcium channels (VGCCs).
More to the Point (Whew!)
Calcium is much, more than a mineral in your bones and teeth. Indeed, [Ca2+]i is a body-wide signaling ion. When it gets loose – i.e., when VGCCs are out of control – all hell breaks loose for your health. Simple as that.
Too much [Ca2+]i in the wrong places is behind a ton of the Diseases of Civilization, including Alzheimer’s Disease.
In a nutshell, cutting through all the scientific gobbledygook, that’s the core of the Alzheimer’s calcium hypothesis.
As a hypothesis, in the truest meaning of the term, it’s an explanation for what can cause AD.
Thus, leaky VGCCs let loose too much [Ca2+]i, thereby leading to AD.
Peeling Back the Onion of Causality
The next logical question becomes, What can cause VGCCs to become so leaky?
Here’s what hundreds of research studies over the past couple of decades point to as the main driver behind out-of-control VGCCs: wireless communications.
One scientist, Dr. Martin Pall (Professor Emeritus at Washington State University) has been a leading light for explaining how WiFi drives VGCCs nuts.
For that reason, I’ve included a few key articles by Dr. Pall in the references section at the end of this post.
Regarding AD, one of his articles in particular says it all, just in the title: Low Intensity Electromagnetic Fields Act via Voltage-Gated Calcium Channel (VGCC) Activation to Cause Very Early Onset Alzheimer’s Disease: 18 Distinct Types of Evidence (see Pall, 2022).
It’s a pretty technical review of the evidence showing how non-native electromagnetic fields (nnEMFs) are behind the drastic uptick of AD over the past couple of decades, especially in younger and younger people.
As recently as 2020, the age-related changes looked like this:
Note that the numbers come from comparing changes only over a 4-year period. Even so, the ca. 5-fold increase in 30-44 year-olds is outrageous!
How About Older People?
Although I didn’t find the exact type of graph for those older than 65, I found this one predicting the incidence of AD as folks enter older age classes. (It’s of personal interest, since I’m already in that older crowd!)
As you might expect, the odds of getting AD are predicted to accelerate even faster into your 70s and 80s.
What About Younger People?
No summaries are available for what’s happening or might happen to younger folks, under the age of 30.
Nevertheless, AD is already dipping into younger crowds. Some predictions I’ve seen suggest an AD graph of different age groups will eventually have 20-somethings on it, and maybe even teenagers, within a few decades.
How can this be happening?
The answer brings is right back to the Alheimer’s calcium hypothesis.
Specifically, what is driving our internal calcium rampage in the first place?
In answering that question, Dr. Pall presents the best summary I’ve seen for explaining what invokes VGCC activation. It’s represented in this diagram from his review article (Pall, 2022):
It shows a complex array of consequences from nnEMFs, starting with VGCC activation (at the red asterisk).
I know that’s a lot to take in. So I’ll just point you to the key result in the box labeled “Pathophysiological effects.”
That’s just a fancy way of saying, “diseases.”
And AD is one of the biggies.
WiFi: Building a High Alzheimer’s Future
Now that we have a clearly established mechanism of action supporting the Alzheimer’s calcium hypothesis, why is the incidence of AD accelerating at such incredible rates?
The obvious answer is: because WiFi usage is expanding.
We have more access to greater bandwidth and faster communications than ever before.
It started with ‘1G’ and quickly grew to ‘4G’ frequencies.
Now we have 5G. It’s use is growing faster than anything prior to it.
And, unfortunately, it’s the most damaging of all.
Understanding why that’s the case would require taking a peek into some physics. I won’t do that to you now – you’re welcome! – especially since I’ve overwhelmed you with so much physiology already.
Suffice it to say that the frequencies used in 5G, combined with a type of pulsation that is severely incompatible with life on Earth, is already creating bigger issues than ever before.
Oh, and it’s not just about human health, either. All living things are negatively impacted. (see Pall, 2016, in the references section)
And, of course, it’s not just about AD, either.
(E.g., you’ll be shocked to see how it also damages your immune system. I even wrote a short ebook about the role of 5G in the outbreak of COVID-19, here: Surprising Truths Behind the Coronavirus Pandemic. This issue is a real eye-opener. And hardly anyone is talking about it. The super bad news is that it sets the stage for the next pandemic, coming to a neighborhood near you before you know it.)
Rather that expanding on what additional kinds of health damage we can expect, which would make this post even longer, I’ll just give you a document that Dr. Pall wrote for the public.
Actually, it was written for politicians – so maybe he dumbed it down even further.
Specifically, it was submitted to the California State Legislature in 2017. (see Pall, 2017, below; download it here.
I strongly encourage everyone to read it, just not too close to bedtime. It will keep you awake at night. Seriously.
Elon Musk: The Internet Knight in Shining Armor?
Look, everyone agrees that Elon Musk is a tech guru. And he’s made gazillions of dollars based on it.
One such enterprise is SpaceX, his satellite communications company.
His goal it to build the fastest connection to the Internet of Things (IoT) available to every man, woman, and child on Earth.
This means planet-wide 5G from space.
Musk’s SpaceX leads the way, as outlined in these two recent online articles:
Starlink satellites: Everything you need to know about the controversial internet megaconstellation
SpaceX launches world’s 1st 5G satellite to bring global connectivity to Internet of Things
It’s basically an out-of-control health experiment, where you and I and everyone else on the planet are unwitting guinea pigs.
(Oh, and one comment in that first article also cites SpaceX’s activities to be an out-of-control geoengineering experiment that will further disrupt our climate. Sheesh!)
The key phrase is ‘out of control’ – since there are no safety guidelines SpaceX has to measure up to.
Dr. Pall’s letter to the California Legislature explains why. The basic reason comes down to, ‘follow the money‘.
Money runs the planet, not governments. And the wireless communications industry has more money than any other, including Big Pharma.
They’re the ones who own your politicians and, therefore, your government.
Bottom line: As smart as Elon Musk and his fellow communications gurus are, they’re all as dumb as a fern when it comes to human health.
Of course, even if they knew what they were doing, I doubt whether their unbridled greed would let them change anything.
What Can You Do?
First and foremost, AD is one of many diseases caused by mitochondrial dysfunction.
There’s a lot you can do to be as good to your mitochondria as you can. After all, your life and health depend on these little guys and gals in your cells.
On that topic, here’s a good place to get started on learning how to do exactly that: Live Long And Prosper With Healthy Mitochondria.
What else can you do to battle the onslaught of 5G?
I used to tell people they could move away from civilization, maybe become a hermit on a mountaintop somewhere.
That will no longer work. The entire planet will soon be flooded with WiFi from thousands of new satellites from SpaceX, among others.
Thousands!
Oh, maybe could escape some exposure by eschewing the use of WiFi yourself. Yeah, right, like anybody’s going to do that!
Nevertheless, you do have some options, as I briefly explain here: Defending Your Health in a High Tech World – Part 3.
Your best defense, as always, is to keep up with the changes in your electromagnetic environment, including the latest recommendations about what you can do for yourself.
Knowledge is your best friend. Ignorance is your worst enemy.
For that reason, I also suggest finding a good website with articles and resources you need for helping yourself and your family. There are many.
One of my favorites is ElectricSense by Lloyd Burrell.
Lloyd is what I call a ‘canary in a coal mine’.
He developed something called electromagnetic hypersensitivity syndrome (EHS; see Stein and Udasin, 2020, in the reference section).
He literally became sick when using his cell phone. Then his office computer, his TV, and even the radio in his car.
Like those old-time canaries, Lloyd became an early indicator of environmental toxicity, in this case due to damage to him by nnEMFs.
His story is not only fascinating, and a lesson for everyone, it also led to his efforts to help others mitigate the damage from nnEMFs.
His site is one of the best I’ve found for learning about the health impacts of nnEMFs and what you can do about them.
Or, You Could Go Down the Medical Rabbit Hole
Dr. Dale Bredesen, in his 2020 book, The End of Alzheimer’s: The First Program to Prevent and Reverse Cognitive Decline, mentioned that just under 250 drugs for treating AD have been rejected by the FDA.
Although I haven’t checked them all out, I can say that the most common target of these treatments is the amyloid-β plaque that kills brain neurons.
The good news is, many of them succeed in reducing the amyloid-β buildup.
The bad news is, it’s the wrong target.
Indeed, relying on the amyloid-β hypothesis ignores the observation that many centenarians have such ‘AD pathology’ without showing signs of clinical AD. (see Arenaza-Urquijo et al., 2018, and Andersen, 2020, in the references below).
It explains why drugs for reducing amyloid-β plaque formation don’t provide clinically meaningful results.
The latest AD drug to be approved by the FDA is typical.
Note also that such drugs typically only address early onset AD.
What to Know About the Latest AD Drug: Leqembi
Here’s a quick overview of this new drug:
- It’s meant only for for those in the very early stages of AD.
- It provides a 27% reduction in the rate of cognitive decline.
- It’s a monoclonal antibody made to remove a supposed cause of AD, amyloid beta plaque.
- It’s administered via IV every two weeks.
- The latest trial found it to be associated with a dangerous type of brain swelling in nearly 13% of patients and brain bleeding in another 14% or so.
- Depending on supplemental coverage, recent FDA approval opens up Leqembi for Medicare to cover $26,500 annual cost.
Public and professional comments are almost breathless in their expectations for this new drug. A lot like they were the the one before that – Aduhelm – which turned into a PR disaster due to approval irregularities at the FDA. (It was approved for medical use in the U.S. in June, 2021, in a controversial decision that led to the resignation of three advisers to the FDA in the absence of evidence that the medication is effective. It is not approved for general use and as of 2023 Medicare has lowered Part B premiums for it.)
A more thoughtful editorial about Leqembi, published Dec. 3, 2022, appeared in the prestigious medical journal The Lancet, “Lecanemab for Alzheimer’s disease: Tempering hype and hope.” (See news commentary here: We shouldn’t get caught up in the hype over new Alzheimer’s drug: “…the 27% difference in disease progression between the drug and placebo groups translates to a much smaller objective difference in cognitive decline, estimated using the Clinical Dementia Rating sum of boxes (CDR SB) scale that quantifies a range of cognitive and functional domains.The difference between the two groups is 0.45 on the 0 to 18 scale, a difference so subtle that patients who receive the drug and their family members who care for them will not be able to notice the clinical difference. In other words, the difference is statistically significant but not necessarily clinically meaningful.”
[BTW: Citing percentages is the weakest statistical maneuver possible. E.g., a 100% improvement in something could reflect a boost from 1 in a 100,000 to 2 in an 100,000. A stat like the Clincial Dementia Rating, as mentioned above, is much more informative. Regarding Leqembi, for example, the 27% ‘improvement’ disappears into clinical insignificance relative to an actual measurement scale.]
Is the best we’ve got?
Apparently, at least from Big Pharma.
Just don’t hold your breath waiting for something better.
Comments or Questions?
I’d love to hear from you. This and every other post here provides a comment section at the end of the post, exactly for that purpose.
So, by all means, leave me your thoughts.
I would be especially grateful if you point out any flaws in my logic, factual errors, or ordinary typos. (I’ll give you a little ‘huzzah’ in my heart.)
Then I’ll respond as soon as I can.
References
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Arenaza-Urquijo EM, Vemuri P. Resistance vs resilience to Alzheimer disease: Clarifying terminology for preclinical studies. Neurology. 2018 Apr 10;90(15):695-703. doi: 10.1212/WNL.0000000000005303. Epub 2018 Mar 28. PMID: 29592885; PMCID: PMC5894932. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894932/
Cheng KC, Huang CY, Hsieh TC, Chiang HC. Disrupted cellular calcium homeostasis is responsible for Aβ-induced learning and memory damage and lifespan shortening in a model of Aβ transgenic fly. IUBMB Life. 2022 Aug;74(8):754-762. doi: 10.1002/iub.2621. Epub 2022 May 9. PMID: 35531745. https://pubmed.ncbi.nlm.nih.gov/35531745/
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All the best in natural health,
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